SnapShot: Lipid Droplets
نویسندگان
چکیده
منابع مشابه
Small GTPase Rab40c Associates with Lipid Droplets and Modulates the Biogenesis of Lipid Droplets
The subcellular location and cell biological function of small GTPase Rab40c in mammalian cells have not been investigated in detail. In this study, we demonstrated that the exogenously expressed GFP-Rab40c associates with lipid droplets marked by neutral lipid specific dye Oil red or Nile red, but not with the Golgi or endosomal markers. Further examination demonstrated that Rab40c is also ass...
متن کاملExpanding Roles for Lipid Droplets
Lipid droplets are the intracellular sites for neutral lipid storage. They are critical for lipid metabolism and energy homeostasis, and their dysfunction has been linked to many diseases. Accumulating evidence suggests that the roles lipid droplets play in biology are significantly broader than previously anticipated. Lipid droplets are the source of molecules important in the nucleus: they ca...
متن کاملImmunohistochemical staining of lipid droplets with adipophilin in paraffin-embedded glioma tissue identifies an association between lipid droplets and tumour grade
Background: Cytoplasmic lipid droplets are important in cancer metabolism and a clear relationship has been established between their accumulation and increased tumour grade in glioma. The development of the novel immunohistochemical marker adipophilin has proven to be a useful method of detecting lipid droplets in paraffin embedded tissue from many diseases. Our aim was to assess the distribut...
متن کاملRedistribution of macrophage cholesteryl ester hydrolase from cytoplasm to lipid droplets upon lipid loading.
Hydrolysis of intracellular cholesteryl esters (CEs) represents the first step in the removal of cholesterol from lipid-laden foam cells associated with atherosclerotic lesions. Neutral cholesteryl ester hydrolase (CEH) catalyzes this reaction, and we recently cloned the cDNA for the human macrophage CEH and demonstrated increased mobilization of intracellular CE droplets by CEH overexpression....
متن کاملThe Lipid-Droplet Proteome Reveals that Droplets Are a Protein-Storage Depot
BACKGROUND Lipid droplets are ubiquitous organelles that are among the basic building blocks of eukaryotic cells. Despite central roles for cholesterol homeostasis and lipid metabolism, their function and protein composition are poorly understood. RESULTS We purified lipid droplets from Drosophila embryos and analyzed the associated proteins by capillary LC-MS-MS. Important functional groups ...
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عنوان ژورنال:
- Cell
دوره 139 شماره
صفحات -
تاریخ انتشار 2009